hrp0097pl5 | Stem cells organoids and single cell transcriptomics | ESPE2023

Cracking the pituitary stem cell code across life using single-cell transcriptomics and organoid models

Vankelecom Hugo

The pituitary gland dynamically remodels during key timepoints of life to meet the prevailing endocrine demands of the organism. Mechanisms underlying this plasticity remain poorly understood. In particular, it is not clear how the pituitary stem cells are involved and biologically behave during pituitary remodeling processes. Indeed, pituitary stem cells remain highly enigmatic regarding cellular complexity, regulatory circuits, niche make-up and functional role. In our studi...